論文業績


2023  2022  2021 2020 2018-19 2016-17 2014-15 2012-13 2010-11 2008-09 2006-07 2001-05 -2000


2023


  • Kawabe T. Homeostasis and immunological function of self-driven memory-phenotype CD4+ T lymphocytes. Immunological Medicine,46: 1-8, 2023


  • 2022


  • Kawabe T.Memory-phenotype CD4+ T Lymphocytes: A Novel Therapeutic Target in Infectious or Autoimmune Diseases?. JMA J, 5(3):298-306, 2022

  • Sato A, Azuma M, Nagai H, Imai W, Kawaguchi K, Morita M, Okuyama Y, Ishii N, So T. OX40 ligand-mannose-binding lectin fusion protein induces potent OX40 cosignaling in CD4+ T cells. Biol Pharm Bull,45: 1798-1804, 2022

  • Okuyama Y, Okajima A, Sakamoto N, Hashimoto A, Tanabe R, Kawajiri A, Kawabe T, Ishii N. IL-33-ILC2 axis promotes anti-tumor CD8+ T cell responses via OX40 signaling. Biochem Biphys Res Commun,637: 9-16, 2022

  • Terui H, Yamasaki K, Wada-Irimada M, Onodera-Amagai M, Hatchome N, Mizuashi M, Yamashita R, Kawabe T, Ishii N, Abe T, Asano Y, Aiba S. Staphylococcus aureus skin colonization promotes SLE-like autoimmune inflammation via neutrophil activation and the IL-23/IL-17 axis. Sci Immunol, 7:, 2022

  • Kawabe T, Ciucci T, Kim KS, Tayama S, Kawajiri A, Suzuki T, Tanaka R, Ishii N, Jankovic D, Zhu J, Sprent J, Bosselut R, Sher A. Redefining the foreign antigen and self-driven memory CD4+ T cell compartments via transcriptomic, phenotypic, and functional analyses. Front Immunol, 13, 2022

  • Fang D, Cui K, Cao Y, Zheng M, Kawabe T, Hu G, Khillan JS, Li D, Zhong C, Jankovic D, Sher A, Zhao K, Zhu J. Differential regulation of transcription factor T-bet induction during NK cell development and T helper-1 cell differentiation. Immunity, 55:639-655, 2022

  • Kawabe T, Sher A. Memory-phenotype CD4+ T cells: a naturally arising T lymphocyte population possessing innate immune function. Int Immunol, 34(4):189-196, 2022

  • Niihori T, Tanoshima R, Sasahara Y, Sato A, Irie M, Saito-Nanjo Y, Funayama R, Shirota M, Abe T, Okuyama Y, Ishii N, Nakayama K, Kure S, Imaizumi M, Aoki Y. Phenotypic heterogeneity in individuals with MECOM variants in 2 families. Blood Adv, 6: 5257-5261, 2022.

  • Kawahara E, Azuma M, Nagashima H, Omori K, Akiyama S, Fujimori Y, Oishi M, Shibui N, Kawaguchi K, Morita M, Okuyama Y, Ishii N, So T. TNF receptor-associated factor 5 limits IL-27 receptor signaling in CD4+ T lymphocytes. J. Immunol, 208: 342-350, 2022.


  • 2021


  • Maruyama T, Kobayashi S, Nakatsukasa H, Moritoki Y, Taguchi D, Sunagawa Y, Morimoto T, Asao A, Jin W, Owada Y, Ishii N, Iwabuchi Y, Yohimura A, Chen WJ, Shibata H. The curcumin analog GO-Y030 controls the generation and stability of regulatory T cells. Frontiers Immunol.12:687669,2021

  • Tashiro R, Niizuma K, Kasamatsu J, Okuyama Y, Rashad S, Kikuchi A, Fujimura M, Kure S, Ishii N, and Tominaga T. Dysregulation of Rnf 213 gene contributes to T cell response via antigen uptake, processing and presentation. J Cell Physiol.Doi: 10.1002/jcp.30396,2021

  • Sasaki T, Nagashima H, Okuma A, Umaru B, Yamauchi T, Yamasaki K, Aiba S, So T, Ishii N, Owada Y, MaruYama T, Kobayashi S Functional analysis of the transcriptional regulator IκB-ζ in intestinal homeostasis.  Digest Dis Sci. Doi: 10.1007/s10620-021-06958-8,2021

  • Kawabe T, Yi J, Sprent J, Homeostasis of Naive and Memory T Lymphocytes. Cold Spring Harb Perspect Biol. a037879, 2021.


  • 2020


  • Kobayashi S, Phung TH, Kagawa Y, Miyazaki H, Takahashi Y , Asao A, Maruyama T, Yoshimura A , Ishii N, Owada Y: Fatty acid-binding protein 3 controls contact hypersensitivity through regulating skin dermal Vγ4+ γ/δ T cell in a murine model . Allergy, i76:1776-1788, 2020

  • Kobayashi S, Tayama S, Phung TH, Kagawa Y, Miyazaki H, Takahashi Y, Maruyama T, Ishii N, Owada Y: Fatty acid-binding protein 5 limits ILC2-mediated allergic lung inflammation in a murine asthma model. Sc.i Rep. 10: 16617, 2020

  • Sakurai T, Okuyama Y, Kobayashi S, Phung HT, Asao A, Kawabe T , Ndhlovu LC, Riccardi C, Kudo H, Wada M, Nio M, So T, Ishii N: GITR controls intestinal inflammation by suppressing IL-15 dependent NK cell activity. FASEB J. 34: 14820-31, 2020

  • Mishima E, Ishijo M, Kawabe T, Kikuchi K, Akiyama Y, Toyohara T, Suzuki C, Asao A, Ishii N, Fukuda S, Abe T: Germ-free conditions modulate host purine metabolism, exacerbating adenine-induced kidney damage. Toxins , 12: 547, 2020.

  • Kawabe T, Yi J, Kawajiri A, Hilligan K, Fang D, Ishii N, Yamane H, Zhu J, Jankovic D, Kim KS, Tringhieri G, Sher A: Differentiation of innate T-bethigh memory-phenotype CD4+ T lymphocytes is promoted by homeostatic IL-12 derived from CD8alpha + type 1 dendritic cells in steady state. Nat Commun , 11: 3366, 2020

  • Katata Y, Inoue S-I, Asao A, Kobayashi S, Terui H, Inoue-Shibuya A, Abe T, Niihori T, Aiba S, Ishii N, Kure S, Aoki Y: Costello syndrome model mice with a HRAS G12S mutation are susceptible to develop house dust mite-induced atopic dermatitis. Cell Death & Disease , 11: 617, 2020.

  • Kobayashi S, Phung HT, Tayama S, Kagawa Y, Miyazaki H, Yamamoto Y, Maruyama T, Ishii N, Owada Y. : Fatty acid binding protein 3 regulates differentiation of IgM-producing plasma cells. FEBS J , 288:1130-1141, 2020

  • Phung HT, Nagashima H, Kobayashi S, Asano N , Machiyama T, Sakurai T, Tayama S, Asao A, Imatani A ,Kawabe T, Okuyama Y, Ishii N, So T: TRAF5 deficiency ameliorates the severity of dextran sulfate sodium colitis by decreasing TRAF2 expression in non-hematopoietic cells. ImmunoHorizons, 4: 129-139, 2020

  • Niitsuma S , Kudo H, Kikuchi A, Hayashi T, Kumakura S, Kobayashi S, Okuyama Y, Kumagai N, Niihori T, Aoki Y, So T, Funayama R, Nakayama K, Shirota M, Kondo S, Kagami S, Tsukaguchi H, Iijima K, Kure S, and Ishii N.: Biallelic variants/mutations of IL1RAP in patients with steroid-sensitive nephrotic syndrome. Int Immunol, 32: 283-292, 2020

  • Okuyama Y, Nagashima H, Ushio-Fukai M, Croft M, Ishii N, and So T.: IQGAP1 restrains T cell cosignaling mediated by OX40. FASEB J , 34:540-554, 2020

  • Tayama S, Okuyama Y, Phung HT, Asao A, Kobayashi S, Musha T, Machiyama T, Sakurai T, Zhang C, Ushio-Fukai M , Kawabe T, So T, and Ishii N.: IQ motif-containing GTPase-activating protein 1 is essential for the optimal maintenance of lung ILC2s. Int. Immunol , 32: 233-241, 2020

  • Kobayashi S, Shiota Y, Kawabe T, Phung HT, Maruyama T, Owada Y, So T, and Ishii N: TRAF5 promotes plasmacytoid dendritic cell development from bone marrow progenitors.  Biochem Biophys Res Commun . 521:353-35, 2020


  • 2018-2019


  • Kobayashi S, Sakurai T, So T, Shiota Y, Asao A, Phung HT, Tanaka R, Kawabe T, Maruyama T, Kanno E, Kawakami K, Owada Y, and Ishii N: TNF receptor-associated factor 5 limits function of plasmacytoid dendritic cells by controlling IFN regulatory factor 5 expression. J. Immunol. 203:1447-1456, 2019

  • Ishizawa K, Yamanaka M, Saiki Y, Miyauchi E, Fukushige S, Akaishi T, Asao A, Mimori T, Saito R, Tojo Y, Yamashita R, Abe M, Sakurada A, Pham NA, Li M, Okada Y, Ishii T, Ishii N, Kobayashi S, Nagasaki M, Ichinose M, Tsao MS, and Horii A.: CD45+CD326+ Cells are predictive of poor prognosis in non-dmall vell lung cancer patients. Clin Cancer Res. 25: 6756-6763, 2019

  • Kamizato K, Sato S, Shil SK, Umaru BA, Kagawa Y, Yamamoto Y, Ogata M, Yasumoto Y, Okuyama Y, Ishii N, Owada Y, Miyazaki H.: The role of fatty acid binding protein 7 in spinal cord astrocytes in a mouse model of experimental autoimmune encephalomyelitis. Neuroscience 409: 120-129, 2019

  • Kimura M, Nagashima H, Okuyama Y, Ishii N, and So T: TRAF2 and TRAF5 associated with the signal transducing receptor gp130 limit IL-6-driven transphosphorylation of JAK1 through the inhibition of proximal JAK-JAK interaction. Int. Immunol.30: 291-299, 2018

  • Okuyama Y, Tanaka Y, Jiang JJ, Kamimura D, Nakamura A, Ota M, Ohki T, Higo D, Ogura H, Ishii N, Atsumi T, Murakami M: Bmi1 Regulates IκBα Degradation via Association with the SCF Complex. J Immunol 201: 2264-72, 2018.

  • Machiyama T, So T, Okuyama Y, Kobayashi S, Phung HT, Asao A, Harigae H, and Ishii N: TNF receptor associated factor 5 controls oncostatin M-mediated lung inflammation. Biochem Biophys Res Commun. 499: 544-550, 2018

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  • Nagashima H, Okuyama Y, Fujita T, Takeda T, Motomura Y, Moro K, Hidaka T, Omori K, Sakurai T, Machiyama T, Ndlovu LC, Riccardi C, So T, and Ishii N: GITR co-signal in ILC2 controls allergic lung inflammation. J Allergy Clin Immunol. 141: 1939-1943.e8, 2018

  • Zhang X, Xiao X, Lan P, Li J, Dou Y, Chen W,Ishii N, Chen S, Xia B, Chen K, Taparowsky E, Li XC.: OX40 costimulation inhibits Foxp3 expression and Treg induction via BATF3-dependent and independent mechanisms. Cell Rep, 24: 607-618, 2018.


  • 2016-2017


  • Ebina-Shibuya R, Matsumoto M, Kuwahara M, Jang K-J, Sugai M, Ito Y, Funayama R, Nakayama K, Sato Y, Ishii N, Okamura Y, Kinoshita K, Kometani H, Kurosaki T, Muto A, Ichinose M, Yamashita M, and Igarashi K: Inflammatory responses induce an identity crisis of alveolar macrophages leading to pulmonary alveolar proteinosis. J Biol Chem, 292: 18098-18112, 2017

  • Lan P, Fan Y, Zhao Y, Lou X, Monsour HP, Zhang X, Choi Y, Dou Y, Ishii N, Ghobrial RM, Xiao X, Li XC.: TNF superfamily receptor OX40 triggers invariant NKT cell pyroptosis and liver injury. J Clin Invest. 127: 2222-34, 2017

  • Suzuki T, Gao J, Ishigaki Y, Kondo K, Sawada S, Izumi T, Uno K, Kaneko K, Tsukita S, Takahashi K, Asao A, Ishii N, Imai J, Yamada T, Oyadomari S, and Katagiri H.: ER stress protein CHOP mediates insulin resistance by modulating adipose tissue macrophage polarity. Cell Rep. 18: 2045-2057, 2017

  • Lu L, Tanaka Y, Ishii N, Sasano T, and Sugawara S.: CD103+ CD11b- salivary gland dendritic cells have antigen cross-presenting capacity. Eur J Immunol 47: 305-313, 2017.

  • Atsumi T, Suzuki H, Jiang JJ, Okuyama Y, Nakagawa I, Ota M, Tanaka Y, Ohki T, Katsunuma K, Nakajima K, Hasegawa Y, Ohara O, Ogura H, Arima Y, Kamimura D, and Murakami M.: Rbm10 regulates inflammation development via alternative splicing of Dnmt3b. Int Immunol. 29:581-591, 2017.

  • Tanaka Y, Nagashima H, Bando K, Lu L, Ozaki A, Morita Y, Fukumoto S, Ishii N, Sugawara S: Oral CD103-CD11b+ classical dendritic cells present sublingual antigen and induce Foxp3+ regulatory T cells in draining lymph nodes. Mucosal Immunol. 10: 79-90, 2017

  • Akhter N, Takeda Y, Nara H, Araki A,Ishii N, Asao N, and Asao H. Apurinic/apyrimidinic endonuclease 1/redox factor-1 (Ape1/Ref-1) modulates antigen presenting cell-mediated T helper cell type 1 responses. J Biol Chem 291: 23672-23680, 2016

  • Nagashima H, Okuyama Y, Hayashi T, Ishii N, and So T: TNF receptor-associated factor-2 and -5 differentially regulate the instructive IL-6 receptor signaling that requires for Th17 development.: J. Immunol.,196: 4082-89, 2016

  • Hirano T, Kikuchi T, Tode N, Santoso A, Yamada M, Mitsuhashi Y, Komatsu R, Kawabe T, Tanimoto T, Ishii N, Tanaka Y, Nishimura H, Nukiwa T, Watanabe A, and Ichinose M.: OX40 ligand newly expressed on bronchiolar progenitors mediates influenza infection and further exacerbates pneumonia. EMBO Mol. Med.8: 422-36, 2016

  • KawabeT, Suzuki N, Yamaki S, Sun S-l, Asao A, Okuyama Y, So T, Iwakura Y, and Ishii N.: Mesenteric lymph nodes contribute to proinflammatory Th17-cell generation during inflammation of the small intestine in mice. Eur. J. Immunol.46: 1119-31, 2016

  • Shoji T, Saito R, Chonan M, Shibahara I, Sato A, Kanamori M, Sonoda Y, Kondo T, Ishii N, and Tominaga T: Local convection-enhanced delivery of an anti-CD40 agonistic monoclonal antibody induces antitumor effects in mouse glioma models. Neuro-Oncology, 18: 1120-28, 2016

  • Chew GM, Fujita T, Webb GM, Burwitz BJ, Wu HL, Reed JS, Hammond KB, Clayton KL, Ishii N, Abdel-Mohsen M, Liegler T, Mitchell BI, Hecht FM, Ostrowski M, Shikuma CM, Hansen SG, Maurer M, Korman AJ, Deeks SG, Sacha JB, Ndhlovu LC.: TIGIT marks exhausted T cells, correlates with disease progression, and serves as target for immune restoration in HIV and SIV infection. PLoS Patholog, 12: e1005349, 2016

  • Meng J, Jiang JJ, Atsumi T, Bando H, Okuyama Y, Sabharwal L, Nakagawa I, Higuchi H, Ota M, Okawara M, Ishitani R, Nureki O, Higo D, Arima Y, Ogura H, Kamimura D, and Murakami M.: Breakpoint Cluster Region-Mediated Inflammation Is Dependent on Casein Kinase II. J Immunol. 197:3111-3119, 2016


  • 2014-2015


  • So, T, Nagashima H, and Ishii N: TNF receptor-associated factor (TRAF) signaling network in CD4+ T-lymphocytes. Tohoku J. Exp. Med., 236: 139-54, 2015

  • Chonan M, Saito R, Shoji T, Shibahara I, Kanamori M, Sonoda Y, Watanabe M, Kikuchi T, Ishii N, and Tominaga T.: CD40/CD40L expression correlates with the survival of patients with glioblastomas and an augmentation in CD40 signaling enhances the efficacy of vaccinations and prolongs survival in intracranial glioma- and glioma-initiating cell-isografted tumor models. Neuro-Oncology, 17: 1453-62, 2015

  • Shibahara I, Saito R, Zahng R, Chonan M, Kanamori M, Sonoda Y, Kumabe T, Kanehira M, Kikuchi T, So T, Watanabe T, Takahashi H, Iwabuchi E, Tanaka Y, Shibahara Y, Sasano H, Ishii N, and Tominaga T.: OX40 ligand expressed in glioblastoma modulates adaptive immunity depending on the microenvironment: a clue for successful immunotherapy. Mol. Cancer, 14: 41-53, 2015

  • Fujita T, Burwitz BJ, Chew GM, Reed JS, PathakR, Seger E, Clayton KL, Rini JM, Ostrowski MA, Ishii N, Kuroda MJ, Hansen SG, Sacha JB, and Ndhlovu LC.: Expansion of dysfunctional Tim-3-expressing effector memroy CD8+ T cells during simian immunodeficiency virus infection in rhesus macaques. J. Immunol. 193: 5576-5583, 2014

  • Ono C, Yu Z, Kasahara Y, Kikuchi Y, Ishii N, and Tomita H.: Fluorescently activated cell sorting followed by microarray profiling of helper T cell subtypes from human peripheral blood. PloS ONE, 9: e111405, 2014

  • Yamaki S,Ine S, Kawabe T, Okuyama Y, Suzuki N, Soroosh P, Mousavi SF, Nagashima H, Sun S-L, So T/, Sasaki T, Harigae H, Sugamura K, Kudo H, Wada M, Nio M, and Ishii N: OX40 and IL-7 play synergistic roles in the homeostatic proliferation of effector memory CD4+ T cells. Eur. J. Immunol., 44: 3015-3025, 2014

  • Haji Y, Suzuki M, Moriya K, So T, Hozumi K, Mizuma M, Unno M, and Ishii N: Activation of Notch1 promotes development of human CD8+ single positive T cells in humanized mice. Biochem. Biophys. Res. Commun., 447: 346-351, 2014

  • Nagashima H, Okuyama Y, Asao A, Kawabe T, Yamaki S, Nakano H, Croft M, Ishii N, and So T: TNF receptor-associated factor 5 limits inflammatory CD4+ T cell differentiation by antagonizing IL-6-receptor signaling. Nat Immunol,15: 449-456, 2014

  • Kamachi F, Harada N, Usui Y, Sakanishi T, Ishii N, Okumura K, Miyake S, and Akiba H: OX40 ligand regulates splenic CD8-dendritic cell-induced Th2 responses in vivo. Biochem. Biophys. Res. Commun.,444: 235-40, 2014

  • Nagata T, Murata K, Murata R, Sun S-L, Saito Y, Yamaga S, Tanaka N, Tamai K, Moriya K, Kasai N, Sugamura K, and Ishii N: Hepatocyte Growth Factor Regulated Tyrosine Kinase Substrate in the peripheral development and function of B-cells. Biochem. Biophys. Res. Commun., 443:351-356, 2014


  • 2012-2013


  • Horino S, Uchiyama T, So T, Nagashima H, Sun SL, Sato M, Asao A, Haji Y, Sasahara Y, Candotti F, Tsuchiya S, Kure S, Sugamura K, and Ishii N: Gene therapy model of X-linked severe combined immunodeficiency using a modified foamy virus vector. PLoS ONE, 8(8):e71594, 2013

  • Sun SL, Horino S, Itoh-Nakadai A, Kawabe T, Asao A, Takahashi T, So T, Funayama R, Kondo M, Saitsu H, Matumoto N, Nakayama K, and Ishii N: Y-chromosome-linked B- and NK-cell deficiency in mice. J. Immunol, 190: 6209-6220, 2013

  • Kawabe T, Sun SL, Fujita T, Yamaki S, Asao A, Takahashi T, So T, and Ishii N: Homeostatic proliferation of naïve CD4+ T cells in mesenteric lymph nodes generates gut-tropic Th17 cells. J. Immunol. 190: 5788-5798, 2013

  • Ichimura A, Matsumoto S, Suzuki S, Dan T, Yamaki S, Sato Y, Kiyomoto H, Ishii N, Okada K, Matsuo O, Hou F.F, Vaughan D.E, de Strihou Cv, and Miyata T: A small molecule inhibitor to plasminogen activator inhibitor 1 i q nhibits macrophage migration. Arterioscler. Thromb. Vasc. Biol. 33: 935-42, 2013

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