論文業績 2025　 2024　 2023　 2022　 2021 2020 2018-19 2016-17 2014-15 2012-13 2010-11 2008-09 2006-07 2001-05 -2000

2025

Shunichi Tayama, Yuya Kitamura, Kyoga Hiraide, Hibiki Suzuki, Jing Li, Ziying Yang, Ryoji Mitsuwaka, Akihisa Kawajiri, Kosuke Sato, Feng Gao, Taku Nakai, Yuko Okuyama, Tadahisa Numakura, Mitsuhiro Yamada, Tomoaki Ida, Masanobu Morita,Takeshi Kawabe, Takaaki Akaike, Naoto Ishii . Supersulfide controls intestinal inflammation by suppressing CD4+ T cell proliferation . Front Immunol, 16: 1506580, 2025

Ziying Yang, Jing Li, Hideaki Watanabe, Feng Gao, Akihisa Kawajiri, Keita、Koinuma, Kosuke Sato, Yuko Okuyama, Shunichi Tayama, Yoichiro Iwakura, Naoto Ishii, Takeshi Kawabe . Naturally arising memory-phenotype CD4 + T lymphocytes give rise to multiple helper subsets to contribute to tumor immunity while inhibiting GVHD . Cancer Immunology Research, 2025.

2024

Kawajiri A, Li J, Koinuma K, Yang Z, Yoon HJ, Yi J, Nagashima H,Ishii M, Gao F, Sato K, Tayama S, Harigae H, Iwakura Y, Ishii N, Sher A, Ishigaki K, Zhu J, Kim KS, Kawabe T. Naturally arising memory-phenotype CD4+ T lymphocytes contain an undifferentiated population that can generate TH1, TH17, and Treg cells. Science Advances10(49): eadq6618, 2024.

Li J, Yang Z, Kawajiri A, Sato K, Tayama S, Ishii N, Zhu J, Kawabe T. Excess generation and activation of naturally arising memory-phenotype CD4+ T lymphocytes are inhibited by regulatory T cells in steady state. Frontiers in Immunology,Volume 152024. 2024.

2023

Nagai H, Azuma M, Sato A, Shibui N, Ogawara S, Tsutsui Y, Suzuki A, Wakaizumi T, Ito Aya, Matsuyama S, Morita M, Hikosaka K, Mari, Ishii N, So T. Fundamental Characterization of Antibody Fusion-Single-Chain TNF Recombinant Proteins Directed against Costimulatory TNF Receptors Expressed by T-Lymphocytes. Cells,Volume 12, Issue 12June 2023.

Hikosaka K, Mari, Ishii N, So T. Role of tumor necrosis factor receptor-associated factor 5 in B-and T-lymphocytes. Exploration of ImmunologyVolume 3, Issue 1, Pages 40 – 55, 2023

Kawabe T. Homeostasis and immunological function of self-driven memory-phenotype CD4+ T lymphocytes. Immunological Medicine,46: 1-8, 2023

2022

Kawabe T.Memory-phenotype CD4+ T Lymphocytes: A Novel Therapeutic Target in Infectious or Autoimmune Diseases?. JMA J, 5(3):298-306, 2022

Sato A, Azuma M, Nagai H, Imai W, Kawaguchi K, Morita M, Okuyama Y, Ishii N, So T. OX40 ligand-mannose-binding lectin fusion protein induces potent OX40 cosignaling in CD4+ T cells. Biol Pharm Bull,45: 1798-1804, 2022

Okuyama Y, Okajima A, Sakamoto N, Hashimoto A, Tanabe R, Kawajiri A, Kawabe T, Ishii N. IL-33-ILC2 axis promotes anti-tumor CD8+ T cell responses via OX40 signaling. Biochem Biphys Res Commun,637: 9-16, 2022

Terui H, Yamasaki K, Wada-Irimada M, Onodera-Amagai M, Hatchome N, Mizuashi M, Yamashita R, Kawabe T, Ishii N, Abe T, Asano Y, Aiba S. Staphylococcus aureus skin colonization promotes SLE-like autoimmune inflammation via neutrophil activation and the IL-23/IL-17 axis. Sci Immunol, 7:, 2022

Kawabe T, Ciucci T, Kim KS, Tayama S, Kawajiri A, Suzuki T, Tanaka R, Ishii N, Jankovic D, Zhu J, Sprent J, Bosselut R, Sher A. Redefining the foreign antigen and self-driven memory CD4+ T cell compartments via transcriptomic, phenotypic, and functional analyses. Front Immunol, 13, 2022

Fang D, Cui K, Cao Y, Zheng M, Kawabe T, Hu G, Khillan JS, Li D, Zhong C, Jankovic D, Sher A, Zhao K, Zhu J. Differential regulation of transcription factor T-bet induction during NK cell development and T helper-1 cell differentiation. Immunity, 55:639-655, 2022

Kawabe T, Sher A. Memory-phenotype CD4+ T cells: a naturally arising T lymphocyte population possessing innate immune function. Int Immunol, 34(4):189-196, 2022

Niihori T, Tanoshima R, Sasahara Y, Sato A, Irie M, Saito-Nanjo Y, Funayama R, Shirota M, Abe T, Okuyama Y, Ishii N, Nakayama K, Kure S, Imaizumi M, Aoki Y. Phenotypic heterogeneity in individuals with MECOM variants in 2 families. Blood Adv, 6: 5257-5261, 2022.

Kawahara E, Azuma M, Nagashima H, Omori K, Akiyama S, Fujimori Y, Oishi M, Shibui N, Kawaguchi K, Morita M, Okuyama Y, Ishii N, So T. TNF receptor-associated factor 5 limits IL-27 receptor signaling in CD4+ T lymphocytes. J. Immunol, 208: 342-350, 2022.

2021

Maruyama T, Kobayashi S, Nakatsukasa H, Moritoki Y, Taguchi D, Sunagawa Y, Morimoto T, Asao A, Jin W, Owada Y, Ishii N, Iwabuchi Y, Yohimura A, Chen WJ, Shibata H. The curcumin analog GO-Y030 controls the generation and stability of regulatory T cells. Frontiers Immunol.12:687669,2021

Tashiro R, Niizuma K, Kasamatsu J, Okuyama Y, Rashad S, Kikuchi A, Fujimura M, Kure S, Ishii N, and Tominaga T. Dysregulation of Rnf 213 gene contributes to T cell response via antigen uptake, processing and presentation. J Cell Physiol.Doi: 10.1002/jcp.30396,2021

Sasaki T, Nagashima H, Okuma A, Umaru B, Yamauchi T, Yamasaki K, Aiba S, So T, Ishii N, Owada Y, MaruYama T, Kobayashi S Functional analysis of the transcriptional regulator IκB-ζ in intestinal homeostasis.  Digest Dis Sci. Doi: 10.1007/s10620-021-06958-8,2021

Kawabe T, Yi J, Sprent J, Homeostasis of Naive and Memory T Lymphocytes. Cold Spring Harb Perspect Biol. a037879, 2021.

2020

Kobayashi S, Phung TH, Kagawa Y, Miyazaki H, Takahashi Y , Asao A, Maruyama T, Yoshimura A , Ishii N, Owada Y: Fatty acid-binding protein 3 controls contact hypersensitivity through regulating skin dermal Vγ4+ γ/δ T cell in a murine model . Allergy, i76:1776-1788, 2020

Kobayashi S, Tayama S, Phung TH, Kagawa Y, Miyazaki H, Takahashi Y, Maruyama T, Ishii N, Owada Y: Fatty acid-binding protein 5 limits ILC2-mediated allergic lung inflammation in a murine asthma model. Sc.i Rep. 10: 16617, 2020

Sakurai T, Okuyama Y, Kobayashi S, Phung HT, Asao A, Kawabe T , Ndhlovu LC, Riccardi C, Kudo H, Wada M, Nio M, So T, Ishii N: GITR controls intestinal inflammation by suppressing IL-15 dependent NK cell activity. FASEB J. 34: 14820-31, 2020

Mishima E, Ishijo M, Kawabe T, Kikuchi K, Akiyama Y, Toyohara T, Suzuki C, Asao A, Ishii N, Fukuda S, Abe T: Germ-free conditions modulate host purine metabolism, exacerbating adenine-induced kidney damage. Toxins , 12: 547, 2020.

Kawabe T, Yi J, Kawajiri A, Hilligan K, Fang D, Ishii N, Yamane H, Zhu J, Jankovic D, Kim KS, Tringhieri G, Sher A: Differentiation of innate T-bethigh memory-phenotype CD4+ T lymphocytes is promoted by homeostatic IL-12 derived from CD8alpha + type 1 dendritic cells in steady state. Nat Commun , 11: 3366, 2020

Katata Y, Inoue S-I, Asao A, Kobayashi S, Terui H, Inoue-Shibuya A, Abe T, Niihori T, Aiba S, Ishii N, Kure S, Aoki Y: Costello syndrome model mice with a HRAS G12S mutation are susceptible to develop house dust mite-induced atopic dermatitis. Cell Death & Disease , 11: 617, 2020.

Kobayashi S, Phung HT, Tayama S, Kagawa Y, Miyazaki H, Yamamoto Y, Maruyama T, Ishii N, Owada Y. : Fatty acid binding protein 3 regulates differentiation of IgM-producing plasma cells. FEBS J , 288:1130-1141, 2020

Phung HT, Nagashima H, Kobayashi S, Asano N , Machiyama T, Sakurai T, Tayama S, Asao A, Imatani A ,Kawabe T, Okuyama Y, Ishii N, So T: TRAF5 deficiency ameliorates the severity of dextran sulfate sodium colitis by decreasing TRAF2 expression in non-hematopoietic cells. ImmunoHorizons, 4: 129-139, 2020

Niitsuma S , Kudo H, Kikuchi A, Hayashi T, Kumakura S, Kobayashi S, Okuyama Y, Kumagai N, Niihori T, Aoki Y, So T, Funayama R, Nakayama K, Shirota M, Kondo S, Kagami S, Tsukaguchi H, Iijima K, Kure S, and Ishii N.: Biallelic variants/mutations of IL1RAP in patients with steroid-sensitive nephrotic syndrome. Int Immunol, 32: 283-292, 2020

Okuyama Y, Nagashima H, Ushio-Fukai M, Croft M, Ishii N, and So T.: IQGAP1 restrains T cell cosignaling mediated by OX40. FASEB J , 34:540-554, 2020

Tayama S, Okuyama Y, Phung HT, Asao A, Kobayashi S, Musha T, Machiyama T, Sakurai T, Zhang C, Ushio-Fukai M , Kawabe T, So T, and Ishii N.: IQ motif-containing GTPase-activating protein 1 is essential for the optimal maintenance of lung ILC2s. Int. Immunol , 32: 233-241, 2020

Kobayashi S, Shiota Y, Kawabe T, Phung HT, Maruyama T, Owada Y, So T, and Ishii N: TRAF5 promotes plasmacytoid dendritic cell development from bone marrow progenitors.  Biochem Biophys Res Commun . 521:353-35, 2020

2018-2019

Kobayashi S, Sakurai T, So T, Shiota Y, Asao A, Phung HT, Tanaka R, Kawabe T, Maruyama T, Kanno E, Kawakami K, Owada Y, and Ishii N: TNF receptor-associated factor 5 limits function of plasmacytoid dendritic cells by controlling IFN regulatory factor 5 expression. J. Immunol. 203:1447-1456, 2019

Ishizawa K, Yamanaka M, Saiki Y, Miyauchi E, Fukushige S, Akaishi T, Asao A, Mimori T, Saito R, Tojo Y, Yamashita R, Abe M, Sakurada A, Pham NA, Li M, Okada Y, Ishii T, Ishii N, Kobayashi S, Nagasaki M, Ichinose M, Tsao MS, and Horii A.: CD45+CD326+ Cells are predictive of poor prognosis in non-dmall vell lung cancer patients. Clin Cancer Res. 25: 6756-6763, 2019

Kamizato K, Sato S, Shil SK, Umaru BA, Kagawa Y, Yamamoto Y, Ogata M, Yasumoto Y, Okuyama Y, Ishii N, Owada Y, Miyazaki H.: The role of fatty acid binding protein 7 in spinal cord astrocytes in a mouse model of experimental autoimmune encephalomyelitis. Neuroscience 409: 120-129, 2019

Kimura M, Nagashima H, Okuyama Y, Ishii N, and So T: TRAF2 and TRAF5 associated with the signal transducing receptor gp130 limit IL-6-driven transphosphorylation of JAK1 through the inhibition of proximal JAK-JAK interaction. Int. Immunol.30: 291-299, 2018

Okuyama Y, Tanaka Y, Jiang JJ, Kamimura D, Nakamura A, Ota M, Ohki T, Higo D, Ogura H, Ishii N, Atsumi T, Murakami M: Bmi1 Regulates IκBα Degradation via Association with the SCF Complex. J Immunol 201: 2264-72, 2018.

Machiyama T, So T, Okuyama Y, Kobayashi S, Phung HT, Asao A, Harigae H, and Ishii N: TNF receptor associated factor 5 controls oncostatin M-mediated lung inflammation. Biochem Biophys Res Commun. 499: 544-550, 2018

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Nagashima H, Okuyama Y, Fujita T, Takeda T, Motomura Y, Moro K, Hidaka T, Omori K, Sakurai T, Machiyama T, Ndlovu LC, Riccardi C, So T, and Ishii N: GITR co-signal in ILC2 controls allergic lung inflammation. J Allergy Clin Immunol. 141: 1939-1943.e8, 2018

Zhang X, Xiao X, Lan P, Li J, Dou Y, Chen W,Ishii N, Chen S, Xia B, Chen K, Taparowsky E, Li XC.: OX40 costimulation inhibits Foxp3 expression and Treg induction via BATF3-dependent and independent mechanisms. Cell Rep, 24: 607-618, 2018.

2016-2017

Ebina-Shibuya R, Matsumoto M, Kuwahara M, Jang K-J, Sugai M, Ito Y, Funayama R, Nakayama K, Sato Y, Ishii N, Okamura Y, Kinoshita K, Kometani H, Kurosaki T, Muto A, Ichinose M, Yamashita M, and Igarashi K: Inflammatory responses induce an identity crisis of alveolar macrophages leading to pulmonary alveolar proteinosis. J Biol Chem, 292: 18098-18112, 2017

Lan P, Fan Y, Zhao Y, Lou X, Monsour HP, Zhang X, Choi Y, Dou Y, Ishii N, Ghobrial RM, Xiao X, Li XC.: TNF superfamily receptor OX40 triggers invariant NKT cell pyroptosis and liver injury. J Clin Invest. 127: 2222-34, 2017

Suzuki T, Gao J, Ishigaki Y, Kondo K, Sawada S, Izumi T, Uno K, Kaneko K, Tsukita S, Takahashi K, Asao A, Ishii N, Imai J, Yamada T, Oyadomari S, and Katagiri H.: ER stress protein CHOP mediates insulin resistance by modulating adipose tissue macrophage polarity. Cell Rep. 18: 2045-2057, 2017

Lu L, Tanaka Y, Ishii N, Sasano T, and Sugawara S.: CD103+ CD11b- salivary gland dendritic cells have antigen cross-presenting capacity. Eur J Immunol 47: 305-313, 2017.

Atsumi T, Suzuki H, Jiang JJ, Okuyama Y, Nakagawa I, Ota M, Tanaka Y, Ohki T, Katsunuma K, Nakajima K, Hasegawa Y, Ohara O, Ogura H, Arima Y, Kamimura D, and Murakami M.: Rbm10 regulates inflammation development via alternative splicing of Dnmt3b. Int Immunol. 29:581-591, 2017.

Tanaka Y, Nagashima H, Bando K, Lu L, Ozaki A, Morita Y, Fukumoto S, Ishii N, Sugawara S: Oral CD103-CD11b+ classical dendritic cells present sublingual antigen and induce Foxp3+ regulatory T cells in draining lymph nodes. Mucosal Immunol. 10: 79-90, 2017

Akhter N, Takeda Y, Nara H, Araki A,Ishii N, Asao N, and Asao H. Apurinic/apyrimidinic endonuclease 1/redox factor-1 (Ape1/Ref-1) modulates antigen presenting cell-mediated T helper cell type 1 responses. J Biol Chem 291: 23672-23680, 2016

Nagashima H, Okuyama Y, Hayashi T, Ishii N, and So T: TNF receptor-associated factor-2 and -5 differentially regulate the instructive IL-6 receptor signaling that requires for Th17 development.: J. Immunol.,196: 4082-89, 2016

Hirano T, Kikuchi T, Tode N, Santoso A, Yamada M, Mitsuhashi Y, Komatsu R, Kawabe T, Tanimoto T, Ishii N, Tanaka Y, Nishimura H, Nukiwa T, Watanabe A, and Ichinose M.: OX40 ligand newly expressed on bronchiolar progenitors mediates influenza infection and further exacerbates pneumonia. EMBO Mol. Med.8: 422-36, 2016

KawabeT, Suzuki N, Yamaki S, Sun S-l, Asao A, Okuyama Y, So T, Iwakura Y, and Ishii N.: Mesenteric lymph nodes contribute to proinflammatory Th17-cell generation during inflammation of the small intestine in mice. Eur. J. Immunol.46: 1119-31, 2016

Shoji T, Saito R, Chonan M, Shibahara I, Sato A, Kanamori M, Sonoda Y, Kondo T, Ishii N, and Tominaga T: Local convection-enhanced delivery of an anti-CD40 agonistic monoclonal antibody induces antitumor effects in mouse glioma models. Neuro-Oncology, 18: 1120-28, 2016

Chew GM, Fujita T, Webb GM, Burwitz BJ, Wu HL, Reed JS, Hammond KB, Clayton KL, Ishii N, Abdel-Mohsen M, Liegler T, Mitchell BI, Hecht FM, Ostrowski M, Shikuma CM, Hansen SG, Maurer M, Korman AJ, Deeks SG, Sacha JB, Ndhlovu LC.: TIGIT marks exhausted T cells, correlates with disease progression, and serves as target for immune restoration in HIV and SIV infection. PLoS Patholog, 12: e1005349, 2016

Meng J, Jiang JJ, Atsumi T, Bando H, Okuyama Y, Sabharwal L, Nakagawa I, Higuchi H, Ota M, Okawara M, Ishitani R, Nureki O, Higo D, Arima Y, Ogura H, Kamimura D, and Murakami M.: Breakpoint Cluster Region-Mediated Inflammation Is Dependent on Casein Kinase II. J Immunol. 197:3111-3119, 2016

2014-2015

So, T, Nagashima H, and Ishii N: TNF receptor-associated factor (TRAF) signaling network in CD4+ T-lymphocytes. Tohoku J. Exp. Med., 236: 139-54, 2015

Chonan M, Saito R, Shoji T, Shibahara I, Kanamori M, Sonoda Y, Watanabe M, Kikuchi T, Ishii N, and Tominaga T.: CD40/CD40L expression correlates with the survival of patients with glioblastomas and an augmentation in CD40 signaling enhances the efficacy of vaccinations and prolongs survival in intracranial glioma- and glioma-initiating cell-isografted tumor models. Neuro-Oncology, 17: 1453-62, 2015

Shibahara I, Saito R, Zahng R, Chonan M, Kanamori M, Sonoda Y, Kumabe T, Kanehira M, Kikuchi T, So T, Watanabe T, Takahashi H, Iwabuchi E, Tanaka Y, Shibahara Y, Sasano H, Ishii N, and Tominaga T.: OX40 ligand expressed in glioblastoma modulates adaptive immunity depending on the microenvironment: a clue for successful immunotherapy. Mol. Cancer, 14: 41-53, 2015

Fujita T, Burwitz BJ, Chew GM, Reed JS, PathakR, Seger E, Clayton KL, Rini JM, Ostrowski MA, Ishii N, Kuroda MJ, Hansen SG, Sacha JB, and Ndhlovu LC.: Expansion of dysfunctional Tim-3-expressing effector memroy CD8+ T cells during simian immunodeficiency virus infection in rhesus macaques. J. Immunol. 193: 5576-5583, 2014

Ono C, Yu Z, Kasahara Y, Kikuchi Y, Ishii N, and Tomita H.: Fluorescently activated cell sorting followed by microarray profiling of helper T cell subtypes from human peripheral blood. PloS ONE, 9: e111405, 2014

Yamaki S,Ine S, Kawabe T, Okuyama Y, Suzuki N, Soroosh P, Mousavi SF, Nagashima H, Sun S-L, So T/, Sasaki T, Harigae H, Sugamura K, Kudo H, Wada M, Nio M, and Ishii N: OX40 and IL-7 play synergistic roles in the homeostatic proliferation of effector memory CD4+ T cells. Eur. J. Immunol., 44: 3015-3025, 2014

Haji Y, Suzuki M, Moriya K, So T, Hozumi K, Mizuma M, Unno M, and Ishii N: Activation of Notch1 promotes development of human CD8+ single positive T cells in humanized mice. Biochem. Biophys. Res. Commun., 447: 346-351, 2014

Nagashima H, Okuyama Y, Asao A, Kawabe T, Yamaki S, Nakano H, Croft M, Ishii N, and So T: TNF receptor-associated factor 5 limits inflammatory CD4+ T cell differentiation by antagonizing IL-6-receptor signaling. Nat Immunol,15: 449-456, 2014

Kamachi F, Harada N, Usui Y, Sakanishi T, Ishii N, Okumura K, Miyake S, and Akiba H: OX40 ligand regulates splenic CD8-dendritic cell-induced Th2 responses in vivo. Biochem. Biophys. Res. Commun.,444: 235-40, 2014

Nagata T, Murata K, Murata R, Sun S-L, Saito Y, Yamaga S, Tanaka N, Tamai K, Moriya K, Kasai N, Sugamura K, and Ishii N: Hepatocyte Growth Factor Regulated Tyrosine Kinase Substrate in the peripheral development and function of B-cells. Biochem. Biophys. Res. Commun., 443:351-356, 2014

2012-2013

Horino S, Uchiyama T, So T, Nagashima H, Sun SL, Sato M, Asao A, Haji Y, Sasahara Y, Candotti F, Tsuchiya S, Kure S, Sugamura K, and Ishii N: Gene therapy model of X-linked severe combined immunodeficiency using a modified foamy virus vector. PLoS ONE, 8(8):e71594, 2013

Sun SL, Horino S, Itoh-Nakadai A, Kawabe T, Asao A, Takahashi T, So T, Funayama R, Kondo M, Saitsu H, Matumoto N, Nakayama K, and Ishii N: Y-chromosome-linked B- and NK-cell deficiency in mice. J. Immunol, 190: 6209-6220, 2013

Kawabe T, Sun SL, Fujita T, Yamaki S, Asao A, Takahashi T, So T, and Ishii N: Homeostatic proliferation of naïve CD4+ T cells in mesenteric lymph nodes generates gut-tropic Th17 cells. J. Immunol. 190: 5788-5798, 2013

Ichimura A, Matsumoto S, Suzuki S, Dan T, Yamaki S, Sato Y, Kiyomoto H, Ishii N, Okada K, Matsuo O, Hou F.F, Vaughan D.E, de Strihou Cv, and Miyata T: A small molecule inhibitor to plasminogen activator inhibitor 1 i q nhibits macrophage migration. Arterioscler. Thromb. Vasc. Biol. 33: 935-42, 2013

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